I suggest to change the default keybind to something more obscure, like OP suggested. This makes it unlikely to close the game by accident. Ctrl+Alt+Q is good.

It's obviously not good that a certain common key combination just closes the game without warning. This can totally look like a crash. I recently made a 1.0 playthrough and the game suddenly closed one time and I assumed it was a crash. MAYBE I just pressed Ctrl+Q because I sprint so often (but I am not 100% sure).